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PB-22 and 5F-PB-22 ended up the first synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are imagined to are actually synthesized Using the intention of making a artificial cannabinoid prodrug, which might boost absorption and confound detection. Ester bonds are simply biodegradable by spontaneous or endogenous, nonspecific esterase hydrolysis, that has been frequently used in medicinal chemistry to make ester prodrugs.
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